Currently we are developing apps in NodeJS, so that overwolf’s app is bit difficult for me tbh 
Is there any good way to connect NodeJS with overwolf?
Node.js is a server-based Javascript, and Node.js is NOT built to run as a client-side (your browser/app). … So, to answer your question: nope, you can’t develop Overwolf apps using Node.js.
You can develop the Overwolf apps using any client-side JS framework like react, angular, etc.
If you want to add some server code, you should implement it on an external server, and communicate with your Overwolf app through some API calls to your server.